Crotalin preparation.



CHARLES A. WOLF, OF PHILADELPHIA, PENNSYLVANIA. I

GROTALIN PREPARATION.

No Drawing.

and State of Pennsylvan a, have inventedcertain new and useful Improvements in Crotalin Preparations,of which the following is a specification The object of this invention is to prov1de preparations of erotalin characterized by such degree of stability that they W111 not undergo deterioration or loss of eificiency under proper conditions of storage, even for comparatively long periods.

As is known, crotalin is a substance occurrin in the poison glands. of snakes of the genus f rotalus. It is obtained from the glands of the rattlesnake, and is chiefly used as a medicament for epilepsy. It is a highly unstable body of the albuminous type, and is coagulatedor precipitated by the usual preservative agents, including phenol, such precipitation involving loss or impairment of its curative properties.

' I have discovered that crota-lin may be effectively preserved or rendered stable, without impairing its value asa medicament by adding to its aqueous solutions a Specification of Letters. Patent.

Application filed November 7, 191a.

' Patented Apr. 7, 1914. Serial No. 799,758.

very small proportion of trioresol(trikresol),

preferably previously dissolved in glycerin.

My novel preparation may be made as follows: The venom derived from the glands of rattlesnakes is digested at a temperature of 60-70 F., with sufficient distilled water for its solution.' There is then added to this solution a small proportion of tricresol, the preferred proportion being approximately one-half of one per cent. by weight of the venom solution. It is preferred that the tricresol be dissolved, before adding it to the dissolved venom, in a quantity of glycerin sufficient for the purpose.

I claim 1. A new composition of matter containing crotalin and tricresol.

2. As a new composition of matter, a solu-' tion containing crotalin and trioresol, the tricresol in the approximate proportion of one-half of one per cent. by Weight of the crotalin solution.

In testimony whereof I aflix my signature in presence of two witnesses.

CHARLES A. WOLF. Witnesses:

HARRY J. STANDRING, HARRY BECKMAN. 

